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Thesis

Insights into the design of an improved PfRH5 malaria immunogen using vaccine-induced monoclonal antibodies

Abstract:

The causative agent of the most deadly form of malaria, P. falciparum, was identified over 130 years ago, yet this disease still causes 430,000 deaths each year. Although naturally-acquired immunity exists, it requires a heavy and sustained exposure to the parasite, with most succumbing as young children, before this immunity has fully developed. Effective treatments exist but with small-molecule drug resistance on the rise and little in the way of affordable alternatives, the nee...

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Department:
University of Oxford

Contributors

Department:
University of Oxford
Role:
Examiner
Department:
The Crick Institute, London
Role:
Examiner
Department:
University of Oxford
Role:
Supervisor
Department:
University of Oxford
Role:
Supervisor
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Funding agency for:
Daniel G. W. Alanine
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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