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Mechanisms of serotonergic control in fear-related neural circuits and behaviour

Abstract:

Serotonin (5-HT) neurotransmission is strongly implicated in affective psychopathologies, with first-line drugs selectively targeting the 5-HT system. Further evidence for the role of 5-HT as an important regulator of emotional states comes from human gene association studies. These have identified polymorphic variants of the 5-HT transporter (5-HTT) gene with reduced transcription efficacy. Lower 5-HTT expression associates with susceptibility to affective disorders and heightened amygdal...

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Division:
MSD
Department:
Pharmacology
Role:
Author

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Supervisor
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Supervisor
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Funding agency for:
Sengupta, A
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:333590cf-964d-44dd-8f5b-4d492e15f8b2
Deposit date:
2018-02-23

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