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Thesis

The structural basis of immune receptor signalling

Abstract:

This work investigates the mechanisms of binding of T cell receptors (TCRs) to Class I MHC-peptide complexes (pMHC). The structure of a TCR specific for the Melan-A tumour antigen bound to its cognate pMHC was solved to a resolution of 2.5 Å which gives insight into how this TCR could be mutated to optimize binding and subsequently used as a cancer vaccine. Detailed sequence and geometric analyses of all currently available structures of Class I TCR-pMHC complexes revealed that TCRs can bin...

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Institution:
University of Oxford
Oxford college:
St Cross College
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Division of Structural Biology

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Role:
Supervisor
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Funding agency for:
Rebecca K Hamer
Publication date:
2008
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:32312040-2e22-4fe3-b05e-6f868233e27e
Local pid:
ora:1775

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