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Thesis

The role of DNA methylation in the regulation of depot-specific gene expression in human adipose tissue

Abstract:

Adipose tissue is not homogenous as individual fat depots display regional variation in their physiological properties. It follows that body fat distribution is increasingly being recognised as a major determinant of metabolic disease risk. At the cellular level, depot-specific properties are exhibited by adipocyte precursors during in vitro culture and persist for many generations, suggesting these cells retain an ‘intrinsic memory’ of their anatomical origin which is epigenetic in nature...

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Role:
Supervisor
Role:
Supervisor
Institution:
University of Oxford
Oxford college:
Brasenose College
Department:
Medical Sciences Division
Publication date:
2013
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
Oxford University, UK
URN:
uuid:2f927c70-edf9-4187-8228-f52dc71c59cf
Local pid:
ora:8479

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