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Thesis

The role of CD1a-restricted T cells in the pathogenesis of atopic dermatitis

Alternative title:
CD1a, atopic dermatitis
Abstract:

In recent years, T-cells that recognise lipid ligands presented by CD1 molecules have been described. CD1a is highly expressed by Langerhans cells of the epidermis and it has been shown that CD1a-restricted T-cells circulate at high frequencies, infiltrate the skin and recognise natural skin lipids. Epidermal CD1a- expressing cells are enriched in AD lesions, however pathways associated with CD1a presentation and AD have not been studied.

The aim of this project was to investigate t...

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Division:
MSD
Role:
Author

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Role:
Supervisor
Medical Research Council More from this funder
British Association of Dermatologists More from this funder
British Skin Foundation More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:2f038a59-35dd-418a-a50e-489c1e784747
Deposit date:
2017-02-21

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