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Thesis

Mechanisms of cytotoxic lymphocyte-mediated killing

Abstract:

Cytotoxic T cells (CTLs) and Natural Killer (NK) cells eliminate other cells in the context of immune response and homeostasis, with the selective release of cytotoxic molecules, such as granzyme B (GzmB), from their lytic granules (LGs) into the synaptic cleft formed with their targets. Our group used noncorrelative cryo-Soft-X-ray Tomography (cryo-SXT) and stochastic optical reconstruction microscopy, to reveal that these molecules are, in part, released as non-vesicular extracellular parti...

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Authors

More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Research group:
Prof. Michael L. Dustin Group
Oxford college:
Wolfson College
Role:
Author
ORCID:
https://orcid.org/0000-0003-1457-8973

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Supervisor
ORCID:
0000-0003-4983-6389
Institution:
Diamond Light Source
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Supervisor
ORCID:
0000-0003-3059-3065
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Supervisor
ORCID:
0000-0002-3050-7633

More from this funder
Funder identifier:
https://ror.org/05etxs293
Funding agency for:
Margaritaki, O
Grant:
AZT00090
Programme:
Diamond Light Source Studentship
More from this funder
Funder identifier:
https://ror.org/01ahsqc77
Funding agency for:
Margaritaki, O
Grant:
AZT00070
Programme:
Kennedy Trust Prize Studentship

DOI:
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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