Radiation response and tolerance in planarian stem cells

Thesis

Ionizing radiation threatens cellular survival, a property strategically exploited in radiotherapy to eradicate cancer cells. However, the efficacy of radiotherapy is impeded by two co-existing challenges: the presence of radiotolerant cancer stem cells capable of withstanding treatment and subsequently driving cancer recurrence; coupled with collateral damage to normal stem cells, which are typically radiosensitive. Despite the pressing demand for radiotherapy, the underlying mechanisms g...

Expand abstract

Authors: Yap, ZC

• DOI: 10.5287/ora-ovjpkgxe2
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: RNAi screen; radiation biology; DNA damage; bulk RNA sequencing; molecular biology; stem cell biology; single-cell RNA sequencing
• Subjects: Functional genomics; Radiation tolerance; Molecular radiobiology; Genetics; DNA damage; High-throughput nucleotide sequencing; Stem cells--Effect of radiation on; RNA interference