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The role of NUCKS in DNA repair

Abstract:

NUCKS is a vertebrate-specific, extensively post-translationally modified transcriptional regulator whose over- and under- expression is associated with cancer and obesity, respectively. We have previously found that NUCKS protein levels increase in DNA-damaged cells, and other studies have reported DNA damage-dependent NUCKS phosphorylation. However, the full impacts of NUCKS depletion on DNA damage repair has not been established. Addressing this question, we show that NUCKS depletion ac...

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Role:
Supervisor
Role:
Supervisor
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford

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