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Thesis

Therapeutic targeting of PRMT5 and mutant ACVR1 in paediatric glioma

Abstract:

Diffuse Intrinsic Pontine Glioma (DIPG) is a universally fatal paediatric brainstem tumour with a median overall survival of 9-11 months. The unique genetic, anatomical and developmental identity of the tumour means that there are currently no effective chemotherapies or targeted therapies. This thesis aimed to identify and characterise novel targets for the treatment of DIPG. Potential therapeutic opportunities arise from the frequent mutations found in histone H3 (H3K27M) and kinase ACVR1 f...

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Division:
MSD
Department:
NDM
Role:
Author

Contributors

Institution:
University of Oxford
Role:
Supervisor
ORCID:
0000-0001-6757-0436
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Supervisor
ORCID:
0000-0002-1407-2529
More from this funder
Programme:
Oxford-The Simcox Family Scholarship
Funding agency for:
Brown, EJ
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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