Thesis
Investigating the effect of low-dose sulfonylureas on glucagon secretion in diabetes mellitus
- Abstract:
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Background: Diabetes is a multi-hormonal disorder characterised by insufficient insulin secretion and aberrant glucagon secretion with fasting hyperglucagonaemia leading to increased rates of hepatic glucose production, which further exacerbates hyperglycaemia. Sulfonylureas used at low concentrations have been shown to partially restore appropriate glucose-regulated glucagon secretion in isolated islets from donors with type 2 diabetes (T2DM). The main objective of this thesis was ...
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Authors
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Terms of use
- Copyright holder:
- Spiliotis, I
- Copyright date:
- 2018
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