Thesis
Optimising radiotherapy of liver tumours: radiobiology of yttrium-90 microsphere treatment
- Abstract:
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Background: Yttrium-90 selective internal radiotherapy (90Y SIRT) is a treatment aimed at improving tumour control within the liver, from which the disease burden is the most common cause of death. FOXFIRE, SIRFLOX, SARAH and other phase 3 clinical trials of SIRT indicated response in the liver but not increased overall survival. The present work aims to address this phenomenon and hypothesises that optimising treatment around absorbed dose to the liver would result in imp...
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- Files:
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(Preview, Dissemination version, pdf, 8.6MB, Terms of use)
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Authors
Contributors
+ Vallis, K
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Oncology
- Role:
- Supervisor
+ Falzone, N
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Oncology
- Role:
- Supervisor
+ Vojnovic, B
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Oncology
- Role:
- Examiner
+ Bailey, D
- Role:
- Examiner
+ Cancer Research UK
More from this funder
- Funder identifier:
- http://dx.doi.org/10.13039/501100000289
- Funding agency for:
- Vallis, K
- Grant:
- C5255/A15935
+ Medical Research Council
More from this funder
- Funder identifier:
- http://dx.doi.org/10.13039/501100000265
- Funding agency for:
- Vallis, K
- Grant:
- MC_PC_12004
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- Keywords:
- Subjects:
- Deposit date:
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2023-05-15
- ARK identifier:
Terms of use
- Copyright holder:
- Abbott, EM
- Copyright date:
- 2019
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