Thesis
Investigating the dynamics of KDEL receptor signalling
- Abstract:
-
The KDEL receptor (KDELR) is a trafficking receptor which is involved in the retrograde trafficking of ER resident proteins that escaped to the Golgi. For this function, the receptor cycles in COPI and COPII coated vesicles bet en Golgi, where cargo is bound, and the ER, where it is released. KDELR recognises its cargo by an ER retrieval sequence (ERS), the canonical signal consisting of a KDEL peptide motif. Cargo binding and dissociation is regulated by the pH difference between the two org...
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Authors
Contributors
+ Schnell, J
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Biochemistry
- Sub department:
- Biochemistry
- Research group:
- Schnell Group
- Oxford college:
- St John's College
- Role:
- Supervisor
- ORCID:
- 0000-0002-8204-7608
+ Newstead, S
- Division:
- MSD
- Department:
- Biochemistry
- Sub department:
- Biochemistry
- Role:
- Supervisor
- DOI:
- Type of award:
- MSc by Research
- Level of award:
- Masters
- Awarding institution:
- University of Oxford
- Language:
-
English
- Keywords:
- Subjects:
- Deposit date:
-
2022-01-17
Terms of use
- Copyright holder:
- Spoendlin, F
- Copyright date:
- 2022
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