- Abstract:
-
The activity of protein kinases is heavily dependent on the phosphorylation state of the protein. Kinase phosphorylation states have been prepared through biological or enzymatic means for biochemical evaluation, but the use of protein chemical modification as an investigative tool has not been addressed. By chemically reacting a genetically encoded cysteine, phosphocysteine was installed via dehydroalanine as a reactive intermediate. The installed phosphocysteine was intended as a surroga...
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Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
- Department:
- Chemistry Research Laboratory, Department of Chemistry, University of Oxford
- Role:
- Supervisor
- Department:
- Chemical Biology Group, BioTherapeutics Chemistry, WorldWide Medicinal Chemistry, Pfizer, 200 Cambridge Park Drive, Cambridge Massachusetts 01890, United States
- Role:
- Supervisor
- Funding agency for:
- Project
- Type of award:
- DPhil
- Awarding institution:
- University of Oxford
- Language:
- English
- Keywords:
- Subjects:
- Copyright holder:
- Kok Phin Chooi
- Copyright date:
- 2014
Thesis
Synthetic phosphorylation of kinases for functional studies in vitro
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Authors
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+ Benjamin G. Davis
+ Lyn H. Jones
Funding
+ Engineering and Physical Sciences Research Council
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