Thesis
Synthetic phosphorylation of kinases for functional studies in vitro
- Abstract:
-
The activity of protein kinases is heavily dependent on the phosphorylation state of the protein. Kinase phosphorylation states have been prepared through biological or enzymatic means for biochemical evaluation, but the use of protein chemical modification as an investigative tool has not been addressed. By chemically reacting a genetically encoded cysteine, phosphocysteine was installed via dehydroalanine as a reactive intermediate. The installed phosphocysteine was intended as a surroga...
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Authors
Contributors
+ Davis, B
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Chemistry Research Laboratory
Role:
Supervisor
+ Jones, L
Department:
Chemical Biology Group, BioTherapeutics Chemistry, WorldWide Medicinal Chemistry, Pfizer, 200 Cambridge Park Drive, Cambridge Massachusetts 01890, United States
Role:
Supervisor
Funding
Engineering and Physical Sciences Research Council
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Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:2adc517a-2876-4a0b-8ead-e9bf164ebc6f
- Deposit date:
- 2015-11-25
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Terms of use
- Copyright holder:
- Chooi, K; Kok Phin Chooi. Kok Phin Chooi
- Copyright date:
- 2014
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