Interplay between 2-oxoglutarate oxygenases and cancer: studies on the aspartyl/asparaginyl-beta-hydroxylase

Thesis

-

Authors: Pfeffer, I

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: Epidermal growth factor; Hydroxylation; Epidermal growth factor-like domain; Disulfides; Fibrillin; Protein structure; Endoplasmic reticulum; 2-Oxoglutarate; Cyclic peptide; Posttranslational modification; Tumour biomarker; Notch; Coagulation factor; Protein misfolding; Traboulsi syndrome; Metalloenzyme; Cancer; Aspartyl/Asparaginyl-β-hydroxylase; Epidermal growth factor hydroxylase; Calcium homeostasis; Oxygenase; TPR domain
• Subjects: Enzymes; Peptide synthesis; Mass spectrometry; Enzyme inhibition; Chemical biology; Crystallography; Biophysical chemistry; Chemistry & allied sciences; Protein chemistry; Biochemistry; Organic chemistry; Structural biology