Thesis
Investigating APP- and β-amyloid-mediated intercellular spread of protein aggregates in a novel Drosophila Alzheimer’s disease model
- Abstract:
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Amyloids are versatile multifaceted self-assembled nanomaterials, classified by the presence of cross-β-sheet molecular architecture. This stable conformation enables amyloids to play wide-ranging, critical physiological roles often homologous between species. However, mutations or errors in the processing and assembly of proteins with amyloidogenic potential, termed “functional amyloids”, such as amyloid precursor protein (APP), can lead to generation of toxic amyloid species, such the am...
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(Preview, Dissemination version, pdf, 12.9MB, Terms of use)
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Authors
Contributors
+ Wilson, C
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Physiology Anatomy and Genetics
- Role:
- Supervisor
- ORCID:
- 0000-0003-0040-0728
+ Verma, B
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Physiology Anatomy and Genetics
- Role:
- Supervisor
- ORCID:
- 0009-0004-0860-9547
+ Carlyle, B
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Physiology Anatomy and Genetics
- Role:
- Examiner
- ORCID:
- 0000-0003-1491-3217
+ Yun, F
- Role:
- Examiner
- DOI:
- Type of award:
- MSc by Research
- Level of award:
- Masters
- Awarding institution:
- University of Oxford
- Language:
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English
- Keywords:
- Subjects:
- Deposit date:
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2026-02-17
- ARK identifier:
Terms of use
- Copyright holder:
- Adam Arous
- Copyright date:
- 2025
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