Investigation into the relationship between PARPs in DNA repair and synthetic lethality with homologous recombination deficiency

Thesis

The genome of each cell is under constant threat from various forms of DNA damage. In order to protect themselves from this danger, cells possess a number of pathways able to resolve DNA lesions. The addition of poly(ADPribose) is a post-translational modification produced by attaching successive ADP-ribose moieties to a protein acceptor, forming long chains. Enzymes called poly(ADP-ribose) polymerases (PARPs) catalyse the production of these modifications, and a number of different PARP...

Expand abstract

Authors: Ronson, G

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: DNA Repair; PARP; Genome Stability
• Subjects: Biochemistry