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Radiolabelled Bacillus anthracis toxin-based probes for molecular imaging of MMP activity in tumour models

Abstract:

Increased activity of matrix metalloproteinases (MMPs) is associated with poor prognosis and metastasis in different cancer types. To exploit this feature and target cancer cells, the protective antigen (PAWT) of the binary anthrax lethal toxin (LT) was modified to form pores in cell membranes only when cleaved by MMPs (PAL1). Anthrax lethal factor (LF) is then able to translocate through these pores into the cytosol of tumour cells. The aim of this work was to develop a novel non-invasive...

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Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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