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Thesis

The application of click reactions in the synthesis of modified oligonucleotides

Abstract:

'Click' chemistry has been widely applied in nucleic acid studies, the most common reactions being the copper-catalysed and strain promoted alkyne-azide cycloadditions (CuAAC and SPAAC respectively). This thesis describes the use of these complementary reactions in the synthesis of modified oligonucleotides. Both reactions are used to ligate alkyne and azide-modified oligonucleotides together to form larger strands on the solid phase. The CuAAC reaction can produce ODNs containing a bioco...

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Division:
MPLS
Department:
Chemistry
Sub department:
Chemical Biology
Role:
Author

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:29852209-8a1b-4b74-953f-4e895b8c949e
Deposit date:
2016-02-15

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