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Thesis

Preimplantation genetic diagnosis - new methods for the detection of genetic abnormalities in human preimplantation embryos

Abstract:

Preimplantation genetic diagnosis (PGD) refers to the testing of embryos produced through in vitro fertilization (IVF) in order to identify those unaffected by a specific genetic disorder or chromosomal abnormality. In this study, different methodologies were examined and developed for performance of PGD. Investigation of various whole genome amplification (WGA) methods identified multiple displacement amplification as a reliable method for genotyping single cells. Furthermore, this technolog...

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Institution:
University of Oxford
Oxford college:
St Cross College
Department:
Medical Sciences Division - Obstetrics & Gynaecology

Contributors

Role:
Supervisor
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:28611f65-7729-4293-9c3f-4fc3f0cc39d7
Local pid:
ora:7042

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