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Thesis

Investigating the inhibition of endoplasmic reticulum α-Glucosidase II for the development of broad-spectrum antivirals

Abstract:

Enveloped viruses hijack the protein production machinery of their host in order to proliferate and their replication/infectivity relies on the correct folding of their surface glycoproteins. This dependence on glycoprotein quality control for viral proliferation makes the host endoplasmic reticulum quality control (ERQC) mechanisms an attractive target for the development of host-targeting antiviral agents, which may show broad-spectrum activity and a high genetic barrier to resistance. A...

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Division:
MSD
Department:
Biochemistry
Role:
Author

Contributors

Role:
Contributor
Role:
Contributor
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Contributor
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Contributor
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Supervisor
ORCID:
0000-0003-1969-4949
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Name:
Chang-EPA Doctoral Scholarship
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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