Thesis
PCAF, SIRT1 and the regulation of substrate acetylation
- Abstract:
-
Levels of lysine acetylation (KAc) in cells are regulated by epigenetic enzymes with opposing roles; histone acetyl transferases (HATs) and histone deacetylases (HDACs). The HAT p300 CBP associating factor (PCAF) and the sirtuin HDAC SIRT1 have protein substrates in common, including histone 3 (H3) at lysine residues 9 and 14 (H3K9 and H3K14) and non histone protein hypoxia inducible factor 1α (HIF1α). Studying PCAF and SIRT1 in parallel helps understand how levels of acetylation are maint...
Expand abstract
Actions
Access Document
- Files:
-
-
(Preview, Dissemination version, pdf, 13.2MB, Terms of use)
-
Authors
Contributors
+ Kawamura, A
- Institution:
- University of Oxford
- Division:
- MPLS
- Department:
- Chemistry
- Sub department:
- Chemistry Research Laboratory
- Role:
- Supervisor
+ Brennan, P
- Institution:
- University of Oxford
- Division:
- MPLS
- Department:
- Chemistry
- Sub department:
- Chemistry
- Research group:
- Brennan group
- Role:
- Supervisor
+ McCullagh, J
- Institution:
- University of Oxford
- Division:
- MPLS
- Department:
- Chemistry
- Sub department:
- Chemistry Research Laboratory
- Role:
- Examiner
+ Hopkinson, R
- Institution:
- University of Leicester
- Department:
- Chemistry
- Role:
- Examiner
+ Engineering and Physical Sciences Research Council
More from this funder
- Funder identifier:
- http://dx.doi.org/10.13039/501100000266
- Funding agency for:
- Serrano, L
- Grant:
- EP/L015838/1
- Programme:
- Synthesis for Biology and Medicine CDT
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- Keywords:
- Subjects:
- Deposit date:
-
2022-04-08
- ARK identifier:
Terms of use
- Copyright holder:
- Serrano, L
- Copyright date:
- 2021
If you are the owner of this record, you can report an update to it here: Report update to this record