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Thesis

Studies on the inhibition of human hypoxia inducible factor (HIF) hydroxylases

Abstract:

Hypoxia inducible factor (HIF) is an α/β-heterodimeric transcription factor that regulates cellular responses to hypoxia in metazoans. The activity and stability of the HIF-α subunits are regulated by prolyl and asparaginyl hydroxylation. Human HIF-1α prolyl hydroxylation occurs at Pro402 and Pro564 while asparaginyl hydroxylation occurs at Asn803. Asparaginyl hydroxylation blocks the HIF-1α interaction with the p300/CBP co-activator, thus inhibiting HIF transcriptional activation. Prolyl ...

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Research group:
Christopher J Schofield
Oxford college:
Trinity College
Role:
Author

Contributors

Role:
Supervisor

Publication date:
2012
DOI:
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

Language:
English
Keywords:
Subjects:
UUID:
uuid:25d17478-9fdc-4a6c-9204-ab78cfdabd51
Deposit date:
2016-11-15
ARK identifier:

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