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Thesis

Studies on the inhibition of human hypoxia inducible factor (HIF) hydroxylases

Abstract:

Hypoxia inducible factor (HIF) is an α/β-heterodimeric transcription factor that regulates cellular responses to hypoxia in metazoans. The activity and stability of the HIF-α subunits are regulated by prolyl and asparaginyl hydroxylation. Human HIF-1α prolyl hydroxylation occurs at Pro402 and Pro564 while asparaginyl hydroxylation occurs at Asn803. Asparaginyl hydroxylation blocks the HIF-1α interaction with the p300/CBP co-activator, thus inhibiting HIF transcriptional activation. Prolyl ...

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Subgroup:
Organic Chemistry
Research group:
Christopher J Schofield
Oxford college:
Trinity College
Role:
Author

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Role:
Supervisor
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Grant:
Funding agency for:
Yeoh, KK
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:25d17478-9fdc-4a6c-9204-ab78cfdabd51
Language:
English
Keywords:
Subjects:

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