Thesis icon

Thesis

Studies on the inhibition of human hypoxia inducible factor (HIF) hydroxylases

Abstract:

Hypoxia inducible factor (HIF) is an α/β-heterodimeric transcription factor that regulates cellular responses to hypoxia in metazoans. The activity and stability of the HIF-α subunits are regulated by prolyl and asparaginyl hydroxylation. Human HIF-1α prolyl hydroxylation occurs at Pro402 and Pro564 while asparaginyl hydroxylation occurs at Asn803. Asparaginyl hydroxylation blocks the HIF-1α interaction with the p300/CBP co-activator, thus inhibiting HIF transcriptional activation. Prolyl ...

Expand abstract

Actions


Authors


More by this author
Institution:
University of Oxford
Research group:
Christopher J Schofield
Oxford college:
Trinity College
Department:
Mathematical,Physical & Life Sciences Division - Chemistry - Organic Chemistry

Contributors

More from this funder
Funding agency for:
Kar Kheng Yeoh
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Language:
English
Keywords:
Subjects:

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP