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Thesis

R21, a novel particle based vaccine for a multi-component approach to malaria vaccination

Abstract:

Malaria is a major cause of mortality and morbidity and an effective vaccine is an urgent global health priority. This thesis evaluates the liver stage viral vector regimen ChAd63 – MVA ME.TRAP in humans and demonstrates the induction of partial protective efficacy (21%) against sporozoite challenge, mediated by high levels of antigen-specific T cells. Although this efficacy is suboptimal, the only subunit vaccine regimen found to elicit greater efficacy has been the particle va...

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Katharine Collins More by this author

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Role:
Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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