Thesis
Chemoenzymatic methods for GAG chain editing on proteoglycans
- Abstract:
-
Proteoglycans (PGs) are ubiquitous on the cell surface and in the extracellular matrix of almost all mammalian tissues and comprise one of the most complex and multifunctional glycoprotein families. PGs carry one or more complex glycosaminoglycan (GAG) chains on their protein backbone, which are assembled through a multi-step biosynthetic process. These glycoconjugates regulate diverse functions in mammalian physiology but are typically intractable to precise molecular study due, in part, to ...
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Authors
Contributors
+ Davis, B
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Pharmacology
- Role:
- Supervisor
+ Bayley, J
- Institution:
- University of Oxford
- Role:
- Supervisor
+ Russell, A
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Pharmacology
- Role:
- Supervisor
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- Keywords:
- Deposit date:
-
2024-09-16
Terms of use
- Copyright holder:
- Papadakis, G
- Copyright date:
- 2024
- Rights statement:
- All rights reserved.
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