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Thesis

Architecture of the HIV-1 glycan shield

Abstract:

In recent years the glycan shield of the HIV-1 envelope spike (Env) has emerged as a potential target for microbicide and vaccine design. The densely packed glycans on its surface include an intrinsic population of under-processed oligomannose structures, and a number of lectins and broadly neutralising antibodies (bnAbs) have been isolated which are reactive to these ‘non-self’ glycan structures. The potential value of these agents in therapeutic or vaccine contexts depends upon the preva...

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Institution:
University of Oxford
Research group:
Dr Max Crispin
Oxford college:
Linacre College
Department:
Medical Sciences Division - Biochemistry

Contributors

Role:
Supervisor
Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:24f37514-1e8f-41fd-b0c2-20cc376d8252
Local pid:
ora:10640

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