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Thesis

Characterisation of a New p97 Adaptor in Genome Stability

Abstract:

Cells are subjected to constant genotoxic stress arising from both endogenous and exogenous sources which can drive the development of a wide range of diseases, especially cancers. Therefore, repair of these lesions is essential to maintain genomic stability and health. The DNA damage response is a key aspect of this process and requires the temporal and spatial regulation of many different factors to orchestrate the repair process. This requires the action of the AAA ATPase p97 which acts...

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Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author

Contributors

Role:
Supervisor
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Name:
Medical Research Council
Funding agency for:
Wiseman, K
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:24e23965-ac0b-4fd9-8928-990df307b52f
Deposit date:
2018-02-19

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