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Regulation of RNA polymerase II transcription by Spt4 in Saccharomyces cerevisiae

Abstract:

Transcription of RNA polymerase II (RNAPII) through chromatin is coordinated by numerous transcription elongation factors (TEFs). Spt4 and Spt5 are two of the most highly conserved TEFs in organisms with nucleosomes. Spt4 forms a complex with Spt5, known as the DSIF complex in humans, which was discovered several decades ago and extensively studied, yet its exact function is still not well understood. Early experiments showed that spt4 and spt5 mutants share similar phenotypes with histone...

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Division:
MSD
Department:
Biochemistry
Role:
Author

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Supervisor
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Supervisor
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Examiner
Role:
Examiner
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Name:
Cancer Research UK
Funding agency for:
Uzun, Ü
Grant:
C5255/A23225
Programme:
Cancer Research UK Oxford Centre Prize DPhil Studentship
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
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Subjects:
Deposit date:
2020-11-27

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