Thesis
Regulation of RNA polymerase II transcription by Spt4 in Saccharomyces cerevisiae
- Abstract:
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Transcription of RNA polymerase II (RNAPII) through chromatin is coordinated by numerous transcription elongation factors (TEFs). Spt4 and Spt5 are two of the most highly conserved TEFs in organisms with nucleosomes. Spt4 forms a complex with Spt5, known as the DSIF complex in humans, which was discovered several decades ago and extensively studied, yet its exact function is still not well understood. Early experiments showed that spt4 and spt5 mutants share similar phenotypes with histone...
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- Files:
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(Preview, Dissemination version, pdf, 11.1MB, Terms of use)
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Authors
Contributors
+ Furger, A
- Role:
- Supervisor
+ Mellor, J
- Role:
- Supervisor
+ Norbury, C
- Role:
- Examiner
+ Robert, F
- Role:
- Examiner
+ Cancer Research UK
More from this funder
- Funding agency for:
- Uzun, Ü
- Grant:
- C5255/A23225
- Programme:
- Cancer Research UK Oxford Centre Prize DPhil Studentship
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- Keywords:
- Subjects:
- Deposit date:
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2020-11-27
- ARK identifier:
Terms of use
- Copyright holder:
- Uzun, Ü
- Copyright date:
- 2020
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