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Thesis

Catalytic enantioselective methods for challenging polar addition reactions

Abstract:

Chapter 1 serves as an introduction to the fundamental principles of organocatalysis and enantioselective synthesis. Seminal contributions to the evolution of modern superbase catalysis are discussed.

Chapter 2 describes the development of a novel enantioselective direct aldol reaction catalysed by a bifunctional iminophosphorane. The ability of a BIMP catalyst to activate high-pKa aryl methyl ketone pro-nucleophiles is emphasised against the backdrop of traditional Cinchona and th...

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Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author

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Supervisor
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Name:
Bayer
Funder identifier:
http://dx.doi.org/10.13039/100004326
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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