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Thesis

Large-scale layered systems and synthetic biology: model reduction and decomposition

Abstract:

This thesis is concerned with large-scale systems of Ordinary Differential Equations that model Biomolecular Reaction Networks (BRNs) in Systems and Synthetic Biology. It addresses the strategies of model reduction and decomposition used to overcome the challenges posed by the high dimension and stiffness typical of these models. A number of developments of these strategies are identified, and their implementation on various BRN models is demonstrated.

The goal of model reduction is...

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Institution:
University of Oxford
Oxford college:
Trinity College
Department:
Mathematical,Physical & Life Sciences Division - Other - Life Sciences Interface Doctoral Training Centre

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Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:205a18fb-b21f-4148-ba7d-3238f4b1f25b
Local pid:
ora:11689

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