Journal article
Lack of genetic support for shared aetiology of Coronary Artery Disease and Late-onset Alzheimer’s disease
- Abstract:
- Epidemiological studies suggest a positive association between coronary artery disease (CAD) and late-onset Alzheimer’s disease (LOAD). This large-scale genetic study brings together ‘big data’ resources to examine the causal impact of genetic determinants of CAD on risk of LOAD. A two-sample Mendelian randomization approach was adopted to estimate the causal effect of CAD on risk of LOAD using summary data from 60,801 CAD cases from CARDIoGRAMplusC4D and 17,008 LOAD cases from the IGAP Consortium. Additional analyses assessed the independent relevance of genetic associations at the APOE locus for both CAD and LOAD. Higher genetically determined risk of CAD was associated with a slightly higher risk of LOAD (Odds Ratio (OR) per log-odds unit of CAD [95% CI]: 1.07 [1.01–1.15]; p = 0.027). However, after exclusion of the APOE locus, the estimate of the causal effect of CAD for LOAD was attenuated and no longer significant (OR 0.94 [0.88–1.01]; p = 0.072). This Mendelian randomization study indicates that the APOE locus is the chief determinant of shared genetic architecture between CAD and LOAD, and suggests a lack of causal relevance of CAD for risk of LOAD after exclusion of APOE.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, docx, 75.6KB, Terms of use)
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- Publisher copy:
- 10.1038/s41598-018-25460-2
Authors
+ British
Heart Foundation
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- Funding agency for:
- Farrall, M
- Hopewell, JC
- Grant:
- 090532/Z/09/Z
- FS/14/55/30806
+ TriPartite Immunometabolism Consortium
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- Funding agency for:
- Goel, A
- Grant:
- Novo Nordisk Foundation’s Grant number NNF15CC0018486
+ European Union
More from this funder
- Funding agency for:
- Goel, A
- Grant:
- Novo Nordisk Foundation’s Grant number NNF15CC0018486
+ European Commission
More from this funder
- Funding agency for:
- Goel, A
- Grant:
- Novo Nordisk Foundation’s Grant number NNF15CC0018486
- Publisher:
- Springer Nature
- Journal:
- Scientific Reports More from this journal
- Volume:
- 8
- Article number:
- 7102
- Publication date:
- 2018-05-08
- Acceptance date:
- 2018-04-19
- DOI:
- ISSN:
-
2045-2322
- Pubs id:
-
pubs:846584
- UUID:
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uuid:1fdce54b-6c88-43df-98f2-c29c9672af23
- Local pid:
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pubs:846584
- Deposit date:
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2018-05-08
Terms of use
- Copyright holder:
- Grace et al
- Copyright date:
- 2018
- Notes:
- This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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