Journal article
Induced disruption of the iron-regulatory hormone hepcidin inhibits acute inflammatory hypoferremia
- Abstract:
-
Withdrawal of iron from serum (hypoferremia) is a conserved innate immune antimicrobial strategy that can withhold this critical nutrient from invading pathogens, impairing their growth. Hepcidin (Hamp1) is the master regulator of iron and its expression is induced by inflammation. Mice lacking Hamp1 from birth rapidly accumulate iron and are susceptible to infection by blooddwelling siderophilic bacteria such as Vibrio vulnificus. In order to study the innate immune role of hep...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- Karger Publisher's website
- Journal:
- Journal of Innate Immunity Journal website
- Volume:
- 8
- Issue:
- 5
- Pages:
- 517-528
- Publication date:
- 2016-06-01
- Acceptance date:
- 2016-06-20
- DOI:
- ISSN:
-
1662-8128
Item Description
- Keywords:
- Pubs id:
-
pubs:633431
- UUID:
-
uuid:1f69698a-9936-4130-b4d3-f776f5803551
- Local pid:
- pubs:633431
- Source identifiers:
-
633431
- Deposit date:
- 2016-07-12
Terms of use
- Copyright holder:
- Armitage et al
- Copyright date:
- 2016
- Notes:
-
Copyright © 2016 The Author(s) Published by S. Karger AG, Basel. Th is article is licensed under the Creative Commons AttributionNonCommercial-NoDerivatives
4.0 International License (CC BYNC-ND)
(http://www.karger.com/Services/OpenAccessLicense).
Usage and distribution for commercial purposes as well as any distribution
of modifi ed material requires written permission.
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