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A hitchhiker's guide to click-chemistry with nucleic acids

Abstract:

Click chemistry is an immensely powerful technique for the fast and efficient covalent conjugation of molecular entities. Its broad scope has positively impacted on multiple scientific disciplines, and its implementation within the nucleic acid field has enabled researchers to generate a wide variety of tools with application in biology, biochemistry, and biotechnology. Azide-alkyne cycloadditions (AAC) are still the leading technology among click reactions due to the facile modification and ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acs.chemrev.0c00928

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
CHEMISTRY
Sub department:
Organic Chemistry
Role:
Author
ORCID:
0000-0002-6538-3036
Publisher:
American Chemical Society
Journal:
Chemical Reviews More from this journal
Volume:
121
Issue:
12
Pages:
7122–7154
Publication date:
2021-01-14
Acceptance date:
2020-12-10
DOI:
EISSN:
1520-6890
ISSN:
0009-2665
Pmid:
33443411
Language:
English
Keywords:
Pubs id:
1156751
Local pid:
pubs:1156751
Deposit date:
2021-03-09

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