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Thesis

Investigating the inhibitor and substrate diversity of the JmjC histone demethylases

Abstract:

Epigenetic control of gene expression by histone post-translational modifications (PTMs) is a complex process regulated by proteins that can 'read', 'write' or 'erase' these PTMs. The histone lysine demethylase (KDM) family of epigenetic enzymes remove methyl modifications from lysines on histone tails. The Jumonji C domain (JmjC) family is the largest family of KDMs. Investigating the scope and mechanisms of the JmjC KDMs is of interest for understanding the diverse functions of the ...

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Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Eli Lilly and Company More from this funder
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Funding agency for:
Shamo Schiller, R
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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