Thesis
In vitro transgenic models to elucidate the molecular mechanisms of TDP-43 pathology in amyotrophic lateral sclerosis
- Abstract:
-
Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disorder characterized by loss of upper and lower motor neurons. TDP-43 was identified as a major protein component of the characteristic neuronal inclusions and it has been detected in 90% of ALS cases. Furthermore, pathogenic mutations in the gene encoding TDP-43, TARDBP, were found in both sporadic and familial ALS cases.
The aim of this study is to investigate the molecular mechanisms of cell...
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Authors
Contributors
+ Wade-Martins, R
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
+ Talbot, K
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
Funding
Bibliographic Details
- Publication date:
- 2013
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:1d8aa081-342f-4994-ac74-12c6ebdc30c6
- Local pid:
- ora:8955
- Deposit date:
- 2014-09-16
Terms of use
- Copyright holder:
- Mutihac, R
- Copyright date:
- 2013
- Notes:
- This thesis is not currently available in ORA.
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