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Thesis

The evolution of viral diversity

Abstract:

This thesis focuses on the population dynamics of three antigenically diverse RNA viruses: dengue, influenza and HIV-1. It comprises a set of studies highlighting the roles of structural constraints on critical antigenic determinants, interactions between immune responses to different antigenic types, host lifespan, and the degree of mixing between different host populations in determining the epidemiology and within-host dynamics of these pathogen systems.

Dengue exists in humans a...

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Institution:
University of Oxford
Department:
Mathematical,Physical & Life Sciences Division - Zoology

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Role:
Supervisor
Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:1d718b15-af79-4567-84ef-f97f61f75369
Local pid:
ora:6549

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