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Average beta burst duration profiles provide a signature of dynamical changes between the ON and OFF medication states in Parkinson’s disease

Abstract:

Parkinson’s disease motor symptoms are associated with an increase in subthalamic nucleus beta band oscillatory power. However, these oscillations are phasic, and there is a growing body of evidence suggesting that beta burst duration may be of critical importance to motor symptoms. This makes insights into the dynamics of beta bursting generation valuable, in particular to refine closed-loop deep brain stimulation in Parkinson’s disease. In this study, we ask the question “Can average burst ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pcbi.1009116

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Institution:
University of Oxford
Division:
MSD
Sub department:
Clinical Neurosciences
Oxford college:
Brasenose; Brasenose College; Brasenose; Brasenose College; Brasenose; Brasenose College; Brasenose; Brasenose College; Brasenose
Role:
Author
ORCID:
0000-0001-6147-905X
More by this author
Role:
Author
ORCID:
0000-0003-4538-2578
More by this author
Role:
Author
ORCID:
0000-0003-0712-1596
More by this author
Role:
Author
ORCID:
0000-0002-1954-1873
Publisher:
Public Library of Science
Journal:
PLOS Computational Biology More from this journal
Volume:
17
Issue:
7
Article number:
e1009116
Publication date:
2021-07-07
Acceptance date:
2021-05-26
DOI:
EISSN:
1553-7358
Language:
English
Keywords:
Pubs id:
1185675
Local pid:
pubs:1185675
Deposit date:
2021-07-11

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