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Journal article

CDK-Mediator and FBXL19 prime developmental genes for activation by promoting atypical regulatory interactions

Abstract:

Appropriate developmental gene regulation relies on the capacity of gene promoters to integrate inputs from distal regulatory elements, yet how this is achieved remains poorly understood. In embryonic stem cells (ESCs), a subset of silent developmental gene promoters are primed for activation by FBXL19, a CpG island binding protein, through its capacity to recruit CDK-Mediator. How mechanistically these proteins function together to prime genes for activation during differentiation is unknown...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/nar/gkaa064

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
ORCID:
0000-0002-8726-7888
Publisher:
Oxford University Press
Journal:
Nucleic Acids Research More from this journal
Volume:
48
Issue:
6
Pages:
2942–2955
Publication date:
2020-01-30
Acceptance date:
2020-01-21
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Pmid:
31996894
Language:
English
Keywords:
Pubs id:
1083517
Local pid:
pubs:1083517
Deposit date:
2020-03-16

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