Statistical HLA type imputation from large and heterogeneous datasets
An individual's Human Leukocyte Antigen (HLA) type is an essential immunogenetic parameter, influencing susceptibility to a variety of autoimmune and infectious diseases, to certain types of cancer and the likelihood of adverse drug reactions.
I present and evaluate two models for the accurate statistical determination of HLA types for single-population and multi-population studies, based on SNP genotypes. Importantly, SNP genotypes are already available for many studies, so that the...Expand abstract
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- Oxford University, UK
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- Dilthey, A
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- Please note that 2 figures have been removed from this version of the thesis for copyright reasons.
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