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Thesis

Investigation of ʟ-amino acid hydroxylases

Abstract:

Ferrous-iron/2-oxoglutarate(2-OG)-dependent oxygenases have emerged as a widely distributed family of oxygenases. They have applications both in biocatalysis and as pharmaceutical/agrochemical targets. One of the first subfamilies of 2-OG oxygenases to be studied in detail were the prolyl hydroxylases. The work described in my thesis focused on substrate analogue studies on the proline hydroxylases and on a highly unusual type of 2-OG oxygenase that catalyses the production of ethylene fro...

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Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Department:
Chemistry
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Supervisor
Biotechnology & Biological Sciences Research Council More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:1b94c030-8364-4617-bae3-7a59fe13f901
Deposit date:
2016-10-31

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