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The role of CD1a and phospholipase A2 in psoriasis

Abstract:

Psoriasis is a chronic inflammatory skin disease associated with a T helper 17 (Th17) response, yet it has proved challenging to identify relevant peptide-based T cell antigens. Langerhans cells show a differential migration phenotype in psoriatic lesions and express constitutively high levels of CD1a, which presents lipid antigens to T cells. In addition, phospholipase A2 (PLA2) is highly expressed in psoriatic lesions and is known to generate neolipid skin antigens ...

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Division:
MSD
Role:
Author

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:1b35a94d-96ac-4191-8b16-baff69c9cf24
Deposit date:
2016-10-30

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