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Thesis

Structural & biophysical characterisation of M. tuberculosis MmpL3

Abstract:

Tuberculosis (TB) is the leading cause of death from a single infectious agent, with a staggering 10 million people estimated to have contracted the disease in 2019 alone. Whilst treatments for TB exist, continual emergence of drug-resistant strains necessitates urgent development of next-generation antituberculars. A promising new target is the essential glycolipid exporter mycobacterial membrane protein large 3 (MmpL3), a member of the resistance-nodulation-division (RND) superfamily. Mm...

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Sub department:
Biochemistry
Oxford college:
St Anne's College
Role:
Author
ORCID:
0000-0002-5145-9589

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Sub department:
Biochemistry
Oxford college:
Christ Church
Role:
Supervisor
ORCID:
0000-0001-7432-2270
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Supervisor
ORCID:
0000-0003-0912-4483
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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