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Thesis

Novel genetic and molecular properties of meiotic recombination protein PRDM9

Abstract:

Meiotic recombination is a fundamental biological process in sexually reproducing organisms, enabling offspring to inherit novel combinations of mutations, and ensuring even segregation of chromosomes into gametes. Recombination is initiated by programmed Double Strand Breaks (DSBs), the genomic locations of which are determined in most mammals by PRDM9, a rapidly evolving DNA-binding protein. In crosses between different mouse subspecies, certain Prdm9 alleles cause infertility i...

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Division:
MPLS
Department:
Statistics
Department:
University of Oxford
Role:
Author

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Department:
University of Oxford
Role:
Supervisor
Howard Hughes Medical Institute Gilliam Fellowship More from this funder
Marshall Scholarship More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:1afe17c3-5f75-4166-8697-7da1471a5230
Deposit date:
2016-02-18

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