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Thesis

Novel genetic and molecular properties of meiotic recombination protein PRDM9

Abstract:

Meiotic recombination is a fundamental biological process in sexually reproducing organisms, enabling offspring to inherit novel combinations of mutations, and ensuring even segregation of chromosomes into gametes. Recombination is initiated by programmed Double Strand Breaks (DSBs), the genomic locations of which are determined in most mammals by PRDM9, a rapidly evolving DNA-binding protein. In crosses between different mouse subspecies, certain Prdm9 alleles cause infertility i...

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University of Oxford
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University of Oxford
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Grant:
098387/Z/12/Z
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Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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