Genetic, structural, and functional exploration of the restrictive capacity of TRIM proteins against immunodeficiency viruses

Shmona Simpson

Abstract:

HIV-2 differs from HIV-1 in that many infected people experience normal survival, whilst only 20% progress rapidly to AIDS. Understanding mechanisms of delayed HIV-2 disease progression could provide new insights into HIV control. The Caio Community Cohort was established in Guinea-Bissau in the setting of high HIV-2 prevalence. This thesis investigates the role of polymorphic host restriction factors of the TRIM family in HIV-2 outcome. TRIM proteins are a family of E3 ubiquiti...

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APA Style

Simpson, S. (2017). Genetic, structural, and functional exploration of the restrictive capacity of TRIM proteins against immunodeficiency viruses [PhD thesis]. University of Oxford.

MLA Style

Simpson, Shmona. Genetic, Structural, and Functional Exploration of the Restrictive Capacity of TRIM Proteins against Immunodeficiency Viruses. University of Oxford, 2017.

Chicago Style

Simpson, Shmona. 2017. “Genetic, Structural, and Functional Exploration of the Restrictive Capacity of TRIM Proteins against Immunodeficiency Viruses.” PhD thesis, University of Oxford.
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