Thesis
Genetic, structural, and functional exploration of the restrictive capacity of TRIM proteins against immunodeficiency viruses
- Abstract:
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HIV-2 differs from HIV-1 in that many infected people experience normal survival, whilst only 20% progress rapidly to AIDS. Understanding mechanisms of delayed HIV-2 disease progression could provide new insights into HIV control. The Caio Community Cohort was established in Guinea-Bissau in the setting of high HIV-2 prevalence. This thesis investigates the role of polymorphic host restriction factors of the TRIM family in HIV-2 outcome. TRIM proteins are a family of E3 ubiquitin-ligases, ...
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Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
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uuid:1af588ba-603a-4f39-9443-bb1a95d983f5
- Deposit date:
- 2017-05-02
Terms of use
- Copyright holder:
- Simpson, S
- Copyright date:
- 2017
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