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Thesis

Novel transformations on azetidines

Abstract:

This thesis describes transformations on azetidines, with focus on functionalisation α- to N. Direct asymmetric azetidine functionalisation has been a long-standing challenge, with limited examples in the literature. Recent work within the Hodgson group developed the N-tert-butoxythiocarbonyl (Botc) directing/activating group as an effective and practical means to effect asymmetric α-lithiation—electrophile trapping on azetidines. This thesis describes significant expansion and mechanistic...

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Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author

Contributors

Role:
Supervisor
ORCID:
0000-0001-7201-9841
Role:
Examiner
ORCID:
0000-0002-0636-6471
Role:
Examiner
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Name:
Engineering and Physical Sciences Research Council
Funder identifier:
http://dx.doi.org/10.13039/501100000266
Grant:
1809795
Programme:
New transformations of azacycles & application in target synthesis
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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