Thesis
Developing nuclear magnetic resonance spectroscopy and mass spectrometry methods to identify biomarkers and mechanisms in neurological disease
- Abstract:
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Neurological diseases represent a growing global health burden, yet early diagnosis and effective management remain limited by overlapping clinical features, incomplete understanding of pathophysiology, and a lack of scalable, minimally invasive biomarkers. While magnetic resonance imaging (MRI), positron emission tomography (PET), and cerebrospinal fluid (CSF) analysis are standard clinical tools, they are costly, invasive, and often insufficiently sensitive to detect early molecular changes...
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- Files:
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(Preview, Dissemination version, pdf, 68.6MB, Terms of use)
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Authors
Contributors
+ Probert, F
- Institution:
- University of Oxford
- Division:
- MPLS
- Department:
- Chemistry
- Role:
- Supervisor
+ McCullagh, J
- Institution:
- University of Oxford
- Division:
- MPLS
- Department:
- Chemistry
- Role:
- Supervisor
- ORCID:
- 0000-0003-4733-1205
+ Engineering and Physical Sciences Research Council
More from this funder
- Funder identifier:
- https://ror.org/0439y7842
- Grant:
- EP/W524311/1
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- Keywords:
- Subjects:
- Deposit date:
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2026-04-15
- ARK identifier:
Terms of use
- Copyright holder:
- Tereza Kacerova
- Copyright date:
- 2025
- Notes:
- Role of B vitamins in modulating homocysteine and metabolic pathways linked to brain atrophy: Metabolomics insights from the VITACOG trial and Serum GFAP and NfL augment a metabolomics-driven strategy for long-term prediction of multiple sclerosis progression are derived from this thesis.
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