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Structure and mechanism of a molecular rheostat, an RNA thermometer that modulates immune evasion by Neisseria meningitidis

Abstract:

Neisseria meningitidis causes bacterial meningitis and septicemia. It evades the host complement system by upregulating expression of immune evasion factors in response to changes in temperature. RNA thermometers within mRNAs control expression of bacterial immune evasion factors, including CssA, in the 5′-untranslated region of the operon for capsule biosynthesis. We dissect the molecular mechanisms of thermoregulation and report the structure of the CssA thermometer. We show that the RNA th...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/nar/gkw584

Authors


Barnwal, RP More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Funding agency for:
Tang, CM
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Grant:
HHSN272201200025C; P41GM103399; P41RR002301; P41GM103399, S10RR02781, S10RR08438, S10RR023438, S10RR025062, S10RR029220
University of Wisconsin-Madison More from this funder
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Grant:
DMB-8415048, OIA-9977486, BIR-9214394
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Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Volume:
44
Issue:
19
Pages:
9426–9437
Publication date:
2016-07-01
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:188f0f12-2762-4ee3-928d-bced0d00c618
Source identifiers:
632175
Local pid:
pubs:632175

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