- Abstract:
-
Aggregations of fused in sarcoma (FUS), a multifunctional RNA processing protein, define a pathological subtype of both frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), whilst mutations in the FUS gene are causative for ALS. To model the impact of FUS mutations, expression vectors containing the entire genomic sequence of FUS, up and downstream regions, and native promoter sequences have been generated. The constructs have been tagged with a...
Expand abstract - Role:
- Supervisor
- Role:
- Supervisor
- Institution:
- University of Oxford
- Research group:
- Laboratory of Molecular Neurodegeneration
- Oxford college:
- Keble College
- Department:
- Medical Sciences Division - Physiology,Anatomy and Genetics,Department of
- Publication date:
- 2013
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
- URN:
-
uuid:176cbd1b-623e-41cb-9237-cd6c82fc0ad4
- Local pid:
- ora:8470
- Copyright holder:
- Matthew Thomas
- Copyright date:
- 2013
- Notes:
- This thesis is not currently available in ORA.
Thesis
Functional analysis of the ALS/FTD associated gene FUS using a novel in vitro genomic DNA expression system
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Authors
Contributors
+ Richard Wade-Martins
+ Olaf Ansorge
+ Matthew Robert Thomas
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