Thesis
Functional analysis of the ALS/FTD associated gene FUS using a novel in vitro genomic DNA expression system
- Abstract:
-
Aggregations of fused in sarcoma (FUS), a multifunctional RNA processing protein, define a pathological subtype of both frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), whilst mutations in the FUS gene are causative for ALS. To model the impact of FUS mutations, expression vectors containing the entire genomic sequence of FUS, up and downstream regions, and native promoter sequences have been generated. The constructs have been tagged with a...
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Authors
Contributors
+ Wade-Martins, R
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
+ Ansorge, O
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
Funding
Bibliographic Details
- Publication date:
- 2013
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:176cbd1b-623e-41cb-9237-cd6c82fc0ad4
- Local pid:
- ora:8470
- Deposit date:
- 2014-05-22
Terms of use
- Copyright holder:
- Matthew Thomas
- Copyright date:
- 2013
- Notes:
- This thesis is not currently available in ORA.
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