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Functional analysis of the ALS/FTD associated gene FUS using a novel in vitro genomic DNA expression system

Abstract:

Aggregations of fused in sarcoma (FUS), a multifunctional RNA processing protein, define a pathological subtype of both frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), whilst mutations in the FUS gene are causative for ALS. To model the impact of FUS mutations, expression vectors containing the entire genomic sequence of FUS, up and downstream regions, and native promoter sequences have been generated. The constructs have been tagged with a...

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Role:
Supervisor
Role:
Supervisor
Institution:
University of Oxford
Research group:
Laboratory of Molecular Neurodegeneration
Oxford college:
Keble College
Department:
Medical Sciences Division - Physiology,Anatomy and Genetics,Department of
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Funding agency for:
Matthew Robert Thomas
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:176cbd1b-623e-41cb-9237-cd6c82fc0ad4
Local pid:
ora:8470

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