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Thesis

Alpha-synuclein in Parkinson's disease: molecular pathogenesis and development of genome engineering-based silencing approaches

Abstract:

The ability to reprogram adult somatic cells into induced pluripotent stem cells (iPSCs) and subsequent development of protocols for their differentiation into disease-relevant cell types have enabled in-depth molecular analyses of multiple disease states as hitherto impossible. Parkinson’s disease (PD) is one such example, in which the dopaminergic neurons that manifest pathology are embedded in an inaccessible region of the midbrain, the substantia nigra pars compacta, making it unfeasib...

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Supervisor
NIH Oxford-Cambridge Scholars Program More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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