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Thesis

Studies of the MuSK system using molecular dynamics simulations

Abstract:

Formation and maintenance of neuromuscular junctions, as well as signalling from the nerve to the muscle, depends on the concerted action of a number of membrane proteins. Muscle-Specific Kinase (MuSK) and Downstream-of-Kinase 7 (Dok7) are key players in these processes. MuSK acts as the central component in the complexes responsible for nervemuscle communication. Dok7 then regulates full activation of MuSK. Despite available structural data for these proteins, the structure of the overall...

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Amanda Buyan More by this author

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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