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Characterisation of AEBP2: a polycomb repressive complex 2 component

Abstract:

Polycomb complexes act as repressors of transcription at many developmentally important genes. Repression by polycomb-repressive complex 2 (PRC2) is mediated by the deposition of a tri-methylation mark on lysine 27 of the histone H3 tail (H3K27me3). The PRC2 complex consists of three core proteins: EED, SUZ12, and one of either EZH2 or EZH1, which contain the enzymatic activity. The zinc finger containing protein AEBP2 (AE1 binding protein 2) has been co-purified with the PRC2 complex. The...

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Research group:
Professor Neil Brockdorff
Oxford college:
Lincoln College
Role:
Author

Contributors

Division:
MPLS
Department:
Chemistry
Sub department:
Chemical Biology
Role:
Supervisor
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Funding agency for:
Grijzenhout, A
Grant:
090019/Z/09/A
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:159716a1-a03c-44f3-9fd1-0e88328caef6
Local pid:
ora:11523
Deposit date:
2015-05-29

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